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Amorpha-4,11-diene synthase
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Amorpha-4,11-diene synthase : ウィキペディア英語版
Amorpha-4,11-diene synthase

In enzymology, an amorpha-4,11-diene synthase (ADS) () is an enzyme that catalyzes the chemical reaction
:2-trans,6-trans-farnesyl diphosphate (unicode:⇌) amorpha-4,11-diene + diphosphate
Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, amorpha-4,11-diene and diphosphate.
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming). This enzyme is also called amorphadiene synthase.
This enzyme is mainly found in ''Artemisia annua'', a temperate Asian native flowering plant, and ADS catalyzes the first committed step in the antimalarial drug artemisinin synthesis.
== Enzyme Properties ==


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